| Saturday 4th December 2021 |
| Arbroath | 0 - 0 | Raith | |
| Hamilton | 1 - 0 | Dunfermline | |
| Morton | 2 - 2 | Ayr | |
| QOS | 0 - 0 | Partick | 1308 |
| Friday 3rd December 2021 |
| ICT | 1 - 0 | Kilmarnock | |
| Saturday 20th November 2021 |
| Dunfermline | 3 - 0 | Ayr | |
| Kilmarnock | 0 - 1 | Arbroath | |
| Partick | 1 - 0 | Hamilton | |
| Raith | 2 - 1 | Morton | |
| Friday 19th November 2021 |
| QOS | 1 - 2 | ICT | 0 |
| Saturday 13th November 2021 |
| Arbroath | 1 - 1 | QOS | 0 |
| Ayr | 0 - 4 | Partick | |
| Hamilton | 0 - 3 | Raith | |
| ICT | 1 - 2 | Dunfermline | |
| Morton | 0 - 2 | Kilmarnock | |
| Saturday 6th November 2021 |
| Ayr | 2 - 2 | ICT | |
| Dunfermline | 1 - 3 | Morton | |
| Hamilton | 1 - 1 | Arbroath | |
| Kilmarnock | 0 - 1 | Partick | |
| QOS | 1 - 1 | Raith | 0 |
| Saturday 30th October 2021 |
| Arbroath | 4 - 2 | Dunfermline | |
| Kilmarnock | 4 - 0 | QOS | 3992 |
| Morton | 1 - 1 | Hamilton | |
| Partick | 0 - 0 | ICT | |
| Raith | 2 - 1 | Ayr | |
| Tuesday 26th October 2021 |
| Ayr | 0 - 1 | Kilmarnock | |
| Dunfermline | 1 - 1 | Raith | |
| Hamilton | 1 - 0 | QOS | |
| ICT | 0 - 1 | Arbroath | |
| Morton | 0 - 0 | Partick | |
| Saturday 23rd October 2021 |
| Arbroath | 1 - 1 | Ayr | |
| Kilmarnock | 2 - 1 | Hamilton | |
| Partick | 0 - 0 | Dunfermline | |
| QOS | 0 - 0 | Morton | 1093 |
| Raith | 1 - 1 | ICT | |
| Saturday 16th October 2021 |
| Ayr | 2 - 1 | QOS | 1663 |
| Dunfermline | 2 - 2 | Kilmarnock | |
| ICT | 2 - 0 | Morton | |
| Raith | 2 - 1 | Arbroath | |
| Friday 15th October 2021 |
| Hamilton | 1 - 6 | Partick | |
| Saturday 2nd October 2021 |
| Hamilton | 2 - 1 | ICT | |
| Kilmarnock | 1 - 3 | Raith | |
| Morton | 2 - 2 | Arbroath | |
| Partick | 4 - 0 | Ayr | |
| QOS | 1 - 0 | Dunfermline | 1071 |
| Wednesday 29th September 2021 |
| Raith | 1 - 1 | Dunfermline | |
| Sunday 26th September 2021 |
| Raith | 3 - 2 | Partick | |
| Saturday 25th September 2021 |
| Ayr | 0 - 0 | Morton | |
| Dunfermline | 0 - 0 | Hamilton | |
| ICT | 2 - 1 | QOS | 1884 |
| Friday 24th September 2021 |
| Arbroath | 0 - 0 | Kilmarnock | |
| Saturday 18th September 2021 |
| Dunfermline | 0 - 0 | ICT | |
| Hamilton | 0 - 2 | Ayr | |
| Morton | 0 - 1 | Raith | |
| Partick | 0 - 2 | Kilmarnock | |
| QOS | 0 - 2 | Arbroath | |
| Saturday 11th September 2021 |
| Arbroath | 4 - 0 | Hamilton | |
| Ayr | 3 - 1 | Dunfermline | |
| ICT | 3 - 1 | Partick | |
| Kilmarnock | 1 - 0 | Morton | |
| Raith | 0 - 1 | QOS | 1640 |
| Tuesday 7th September 2021 |
| Ayr | 0 - 2 | Raith | |
| Saturday 28th August 2021 |
| Dunfermline | 0 - 3 | Arbroath | |
| Kilmarnock | 0 - 1 | ICT | |
| Partick | 3 - 0 | Morton | |
| QOS | 1 - 2 | Hamilton | 0 |
| Saturday 21st August 2021 |
| Arbroath | 3 - 1 | Partick | |
| Hamilton | 0 - 2 | Kilmarnock | |
| ICT | 1 - 0 | Ayr | |
| Morton | 2 - 3 | QOS | 1400 |
| Saturday 7th August 2021 |
| Ayr | 2 - 2 | Arbroath | |
| Dunfermline | 0 - 3 | Partick | |
| Hamilton | 0 - 1 | Morton | |
| ICT | 1 - 0 | Raith | |
| QOS | 0 - 1 | Kilmarnock | |
| Monday 2nd August 2021 |
| Kilmarnock | 2 - 0 | Ayr | |
| Saturday 31st July 2021 |
| Arbroath | 0 - 1 | ICT | |
| Morton | 2 - 2 | Dunfermline | |
| Partick | 3 - 2 | QOS | 1564 |
| Raith | 4 - 4 | Hamilton | |